New PDF release: Abeta Peptide and Alzheimer’s Disease: Celebrating a Century

By David H. Small BSc, PhD (auth.), Colin J. Barrow BSc (Hons),PhD, MBA, David H. Small BSc, PhD (eds.)

ISBN-10: 1846284406

ISBN-13: 9781846284403

ISBN-10: 1852339616

ISBN-13: 9781852339616

Abeta Peptide and Alzheimer’s illness summarizes present wisdom of beta-amyloid peptide (Aß) and its position because the significant wrongdoer in Alzheimer’s affliction (AD), proven through fresh advances in genetics and mind biochemistry.

Written by means of leaders within the business and educational international focusing on this swiftly relocating sector, the publication covers primary biochemical stories at the Aß peptide, the genetic impression on Aß expression and processing, and numerous advert healing innovations that concentrate on Aß. even supposing particularly targeting Aß and advert, there's additionally a few dialogue at the similarity and transformations of this peptide and advert with different amyloidogenic illnesses, equivalent to prion sickness, Parkinson’s and Huntington’s.

This ebook will essentially be of curiosity to advert researchers and clinicians but in addition to researchers of different amyloid diseases.

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Additional info for Abeta Peptide and Alzheimer’s Disease: Celebrating a Century of Research

Example text

149. , Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene. Nat Genet, 1992. 1(3):218-221. 150. , Peptides homologous to the amyloid protein of Alzheimer’s disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation. Biochem Biophys Res Commun, 1991. 179(3):1247-1254. 151. , Secretases as targets for the treatment of Alzheimer’s disease. Mol Med Today, 2000. 6(10): 392-397. 152. , Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide.

J Neurochem, 2001. 76(4):1050-1056. 273. , Efficient reversal of Alzheimer’s disease fibril formation and elimination of neurotoxicity by a small molecule. Proc Natl Acad Sci U S A, 2004. 274. , Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer’s disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology. Brain Res, 2001. 913(1):57-67. 275. , Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer’s disease brain.

Onset of dementia is associated with apolipoprotein E epsilon4 in Down’s syndrome. Ann Neurol, 1996. 40(5):799-801. 196. , Small vessel disease and Alzheimer’s dementia: pathological considerations. Cerebrovasc Dis, 2002. 13(Suppl 2):48-52. 197. , Amyloid deposition in cerebrovascular angiopathy. Ann N Y Acad Sci, 1997. 826:463-471. 198. , et al. Imaginem Oblivionis: The prospects of neuroimaging for early detection of Alzheimer’s disease. J Clin Neurosci, 2005. 12:221-230. L. Villemagne et al.

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Abeta Peptide and Alzheimer’s Disease: Celebrating a Century of Research by David H. Small BSc, PhD (auth.), Colin J. Barrow BSc (Hons),PhD, MBA, David H. Small BSc, PhD (eds.)


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