By Vittorio E. Andreucci (auth.), Vittorio E. Andreucci (eds.)
`No doubt than it good merits its position within the library of the younger and no more younger nephrologists either in most cases within the scientific perform or in research.'
`The e-book is an updated and necessary compendium of present wisdom within the medical administration of acute renal failure.'
Journal of the Royal Society of medication, seventy eight (1985)
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Extra info for Acute Renal Failure: Pathophysiology, Prevention, and Treatment
Thus, it has been recently demonstrated that the high interstitial hydrostatic pressure in the kidneys of rats with ECV expansion is associated with a reduced feedback sensitivity, while the low interstitial pressure observed in rats in conditions of dehydration, hypotension, or hypovolemia is associated with an increased feedback sensitivity [234}. These observations may account for the protection of acute salt loading against experimental ARF. ) may influence renin secretion as well as the TGF [235} in a manner still controversial.
Since O 2 consumption by the kidney is mostly due to tubular reabsorption of filtrate, it is not surprising that tubular epithelia are the renal structures most sensitive to the hypoxic insult and that the initiating event of A TN is the dramatic reduction in proximal tubular reabsorption [140}. The latter phenomenon may activate the TGF mechanism in a fashion quite similar to that postulated in nephrotoxic ARF. 2 GLOMERULAR HEMODYNAMICS; RBF AND GFR REGULATION The main sites of resistance in the renal vasculature may be located in the afferent and efferent arterioles and, possibly, in the interlobular arteries.
These observations, therefore, argue against an important role of both intrarenal renin and TGF either in inducing or influencing the severity of ischemic or nephrotoxic ARF: renin suppression confers, in fact, no protection against experimental ARF [127}. NaCl intake and/or excretion may influence the severity of ARF, but this influence seems to occur regardless of the ]GA renin activity [127, 228}. In other words, NaCl has an independent effect on renal cortical renin content and on the severity of ARF.
Acute Renal Failure: Pathophysiology, Prevention, and Treatment by Vittorio E. Andreucci (auth.), Vittorio E. Andreucci (eds.)