Download PDF by Annette M. Doherty: Annual Reports in Medicinal Chemistry, Vol. 40

By Annette M. Doherty

ISBN-10: 0120405407

ISBN-13: 9780120405404

Annual reviews in Medicinal Chemistry maintains to attempt to supply well timed and demanding stories of significant themes in medicinal chemistry including an emphasis on rising subject matters within the organic sciences that are anticipated to supply the foundation for solely new destiny therapies.Volume 34 keeps the commonplace structure of past volumes, this 12 months with 33 chapters. Sections I-IV are disease-oriented and usually record on particular medicinal brokers with updates from quantity 33 on antithrombotics, neurokinin receptor antagonists, anticoagualants, and new antibacterials. As in previous volumes, annual updates were constrained to simply the main lively components of analysis in prefer of particularly concentrated and mechanistically orientated chapters, the place the target is to supply the reader with an important new leads to a selected box. Sections V and VI proceed to stress very important subject matters in medicinal chemistry, biology, and drug layout in addition to the serious interfaces between those disciplines. This quantity concludes with To marketplace, To Market-a bankruptcy on NCE and NBE introductions around the world in 1998, a bankruptcy on pharmagenomics, and at last one on malaria as a 3rd global illness wanting a primary global drug improvement.

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J. Naylor, Cur. Drug Targets – CNS & Neurol. Disorders, 2004, 3, 27. Z. H. Israili, Curr. Med. Chem. – Central Nervous System Agents, 2001, 1, 171. M. Dukat, Curr. Med. Chem. – Central Nervous System Agents, 2004, 4, 77. M. Modica, M. Santagati, S. Guccione, F. Russo, A. Cagnotto, M. Goegan and T. Mennini, Eur. J. Med. , 2000, 35, 1065. A. Cappelli, M. Anzini, S. Vomero, L. Mennuni, F. Makovec, E. Doucet, M. Hamon, M. C. Menziani, P. G. De Benedetti, G. Giorgi, C. Ghelardini and S. Collina, Biorg.

Structural biology 5. Conclusions References 35 36 37 44 45 45 1. INTRODUCTION Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder which imparts tremendous suffering upon more than 20 million people worldwide [1]. Current marketed therapy treats the symptoms and not the etiology of the disease, with cholinesterase inhibitors prescribed for mild to moderate AD and the NMDA antagonist memantine for moderate to severe AD [2]. There is broad consensus that amyloid peptides are involved in the progression of the disease [3–8].

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Annual Reports in Medicinal Chemistry, Vol. 40 by Annette M. Doherty

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