By Michael E. Aulton BPharm PhD FAAPS FSP FRPharmS, Kevin M.G. Taylor BPharm PhD FAAPS FRPharmS
Pharmaceutics is among the such a lot various topic parts in all of pharmaceutical technological know-how. briefly, it truly is inquisitive about the medical and technological features of the layout and manufacture of dosage varieties or medicinal drugs. An figuring out of pharmaceutics is for this reason very important for all pharmacists and people pharmaceutical scientists who're concerned with changing a drug or a possible drug right into a drugs that may be introduced properly, successfully and with ease to the patient.
Now in its fourth variation, this best-selling textbook in pharmaceutics has been introduced thoroughly modern to mirror the quick advances in supply methodologies through eye and injection, advances in drug formulations and supply equipment for specified teams (such as childrens and the elderly), nanomedicine, and pharmacognosy. even as the editors have striven to keep up the accessibility of the textual content for college kids of pharmacy, maintaining the stability among being a certainly pitched introductory textual content and a transparent mirrored image of the kingdom of the art.
provides a logical, entire account of drug layout and manufacture
includes the technological know-how of formula and drug delivery
designed and written for beginners to the layout of dosage forms
New to this edition
New editor: Kevin Taylor, Professor of scientific Pharmaceutics, institution of Pharmacy, college of London.
Twenty-two new contributors.
Six new chapters overlaying parenteral and ocular supply; layout and management of medications for the youngsters and aged; the most recent in plant medications; nanotechnology and nanomedicines, and the supply of biopharmaceuticals.
Thoroughly revised and up-to-date all through.
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Extra resources for Aulton's Pharmaceutics: The Design and Manufacture of Medicines
P a rts Pharmacopoeias give information on the approximate solubility of of cial substances in terms of the number of ‘parts’ of solute dissolved in a stated number of ‘parts’ of solution. Use of this method to describe the concentration of a solution of a solid in a liquid suggests that a certain number of parts by weight (g) of solid are contained in a given number of parts by volume (mL) of solution. In the case of solutions of liquids in liquids, parts by volume of solute in parts by volume of solution are intended, whereas with solutions of gases in liquids, parts by weight of gas in parts by weight of solution are inferred.
Speculation on what is likely to be a good solvent is usually based on the ‘like dissolves like’ principle. 1 *This term is absent from the PhEur. 28 Dis s o lu tio n a n d s o lu b ility That is, a solute dissolves best in a solvent with similar chemical properties. The concept traditionally follows two rules: 1. Polar solutes dissolve in polar solvents. 2. Non-polar solutes dissolve in non-polar solvents. Chemical groups that confer polarity to their parent molecules are known as polar groups.
2 • Schematic representation of the replacement of crystal molecules with solvent molecules during dissolution. 22 This step involves transport of the drug molecules away from the solid/ liquid interface into the bulk of the liquid phase under the in uence of diffusion or convection. Boundary layers are static or slowmoving layers of liquid that surround all solid surfaces that are surrounded by liquid (discussed further later in this chapter and in Chapter 6). Mass transfer takes place more slowly (usually by diffusion; Chapter 3) through these static or slow-moving layers that inhibit the movement of solute molecules from the surface of the solid to the bulk of the solution.
Aulton's Pharmaceutics: The Design and Manufacture of Medicines by Michael E. Aulton BPharm PhD FAAPS FSP FRPharmS, Kevin M.G. Taylor BPharm PhD FAAPS FRPharmS