By Edith Mathiowitz, Donald E. Chickering III, Claus-Michael Lehr
This precious reference offers a finished evaluate of the fundamental equipment for characterizing bioadhesive fabrics and enhancing automobile concentrating on and uptake-offering probabilities for reformulating present compounds to create new prescription drugs at reduce improvement expenditures. Evaluates the original provider features of bioadhesive polymers and their strength to reinforce localization of introduced brokers, neighborhood bioavailability, and drug absorption and delivery! Written by means of over 50 foreign specialists and reflecting vast wisdom of either conventional bioadhesive suggestions and novel scientific purposes, Bioadhesive Drug supply platforms ·discusses mechanical and chemical bonding, polymer-mucus interactions, the impression of floor power in bioadhesion, polymer hydration, and mucus rheology ·analyzes biochemical houses of mucus and glycoproteins, cellphone adhesion molecules, and mobile interplay with - and three-d surfaces ·covers microbalances and magnetic strength transducers, atomic strength microscopy, direct measurements of molecular point adhesions, and techniques to degree cell-cell interactions ·examines bioadhesive vendors, diffusion or penetration enhancers, and lectin-targeted autos ·describes vaginal, nasal, buccal, ocular, and transdermal drug supply ·reviews bioadhesive interactions with the mucosal tissues of the attention and mouth, and people within the respiration, urinary, and gastrointestinal tracts ·explores problems with product improvement, medical trying out, and construction ·and extra! Amply referenced with over 1400 bibliographic citations, and illustrated with greater than three hundred drawings, images, tables, and show equations, Bioadhesive Drug supply platforms serves as a legitimate foundation for innovation in bioadhesive platforms and a very good advent to the topic. This detailed reference is perfect for pharmaceutical scientists and technologists; chemical, polymer, and plastics engineers; biochemists; actual, floor, and colloid chemists; biologists; and upper-level undergraduate and graduate scholars in those disciplines.
Read or Download Bioadhesive drug delivery systems: fundamentals, novel approaches, and development PDF
Best pharmacy books
Discusses actual, chemical, and organic techniques to drug concentrating on expertise, targeting oral, dispersed process, topical, dermal, transdermal, and inhalation supply, and the advance of unique formulations matched through leading edge equipment layout. For researchers.
The pharmaceutical all over the world is a quickly burgeoning contributing to development of gross household product and employment. Technological swap during this box has been very speedy, with many new items being brought. consequently partially, wellbeing and fitness care budgets in the course of the international have elevated dramatically, eliciting starting to be pressures for expense containment.
This article is dedicated to pharmaceutical freeze-drying in all its kinds and in all its technological diversifications. even if you freeze-dry nonsterile drugs otherwise you lyophilize injectables, this ebook covers all of the technological and regulatory specifications. Written by way of a panel of major practitioners within the pharmaceutical -- construction specialists, regulatory inspectors, technical specialists, and gear providers -- the data is suitable, usable, and well timed.
Bringing a brand new drug to industry is a expensive time-consuming strategy. elevated nearby and foreign law over the past 20 years, whereas invaluable, has purely served to enlarge those expenses. in accordance with this escalation, developmental concepts have shifted in the direction of a extra international technique. with a purpose to create the main economical and secure approaches, it truly is severe for these bringing medicinal drugs to industry to appreciate either the globally accredited rules and the neighborhood adaptations.
- Pharmaceutical Preformulation
- FASTtrack: Pharmaceutics - Drug Delivery and Targeting
- Quality (Pharmaceutical Engineering Series)
- Principles and Practice of Pharmaceutical Medicine, Third Edition
- Progress in the Chemistry of Organic Natural Products
Additional resources for Bioadhesive drug delivery systems: fundamentals, novel approaches, and development
M. Brewster, T. Loftsson, J. Baldvinsdottir, and N. Bodor, lnt. J. , 75, R5-R8 (1991). 38. H. Yalkowsky, E. Davis, and T. Clark, J. Pharm. , 82, 978 (1993). 39. S. A. A. Pagliaro, J. Pharm. , 80, 674-676 (1991). 40. L. Ho, A. K. Sugden, Int. J. , 107, 199-203 (1994). 41. F. Tateo, L. Triangeli, E. Ciserchia, R. Nicoletti, and F. Berte, Boll. Chim. , 125, 404-409 (1986). 42. A. , Wiley-Interscience, New York, PP. 147-150 (1982). 43. S. Takahashi, E. Suzuki, and N. Nagashima, Bull. Chem. Soc. , 59, 1129-1132 (1986).
7, 593-599 (1990). 33. K. T. Borchardt, Pharm. , 7, 703-711 (1990). ASPARTAME 53 34. T. Tuncel and A. Araman, Acta Pharmaceutica Turcica, 31, 61-66 (1989). 35. T. Ozol, Acta Pharm. Turcica,; 28, 125-130 (1986). 36. T. Ojima, N. Nagashima, and T. Ozawa, Eur. Patent 0,097,950-B1 (1983). 37. M. Brewster, T. Loftsson, J. Baldvinsdottir, and N. Bodor, lnt. J. , 75, R5-R8 (1991). 38. H. Yalkowsky, E. Davis, and T. Clark, J. Pharm. , 82, 978 (1993). 39. S. A. A. Pagliaro, J. Pharm. , 80, 674-676 (1991).
A. , Wiley-Interscience, New York, PP. 147-150 (1982). 43. S. Takahashi, E. Suzuki, and N. Nagashima, Bull. Chem. Soc. , 59, 1129-1132 (1986). 44. M. Maheswaran and S. Divakar, Indian J. , 30A, 30-34 (1991). 45. D. A. J. B. W. H. Perrin, Int. J. , 86, 263-265 (1992). 46. A. H. Schulpis, G. Reclos, and G. , 31,405-407(1998). 47. J. , Milwaukee, p. 1005H (1981 ). 48. F. Lelj, T. A. Toniolo, J. Am. Chem. , 98, 6669-6675 (1976). 49. A. Castiglione-Morelli, F. Lelj, F. Naider, M. Tallon, T. A. Temussi, 3:.
Bioadhesive drug delivery systems: fundamentals, novel approaches, and development by Edith Mathiowitz, Donald E. Chickering III, Claus-Michael Lehr