Bioinformatics and Functional Genomics, Second Edition - download pdf or read online

By Jonathan Pevsner

ISBN-10: 0470085851

ISBN-13: 9780470085851

ISBN-10: 0470451491

ISBN-13: 9780470451496

The bestselling creation to bioinformatics and sensible genomics—now in an up-to-date version

extensively got in its earlier version, Bioinformatics and practical Genomics deals the main broad-based advent to this explosive new self-discipline. Now in a completely up-to-date and accelerated Second Edition, it remains to be the go-to resource for college students and pros thinking about biomedical learn.

This version offers up to date insurance of the fields of bioinformatics and genomics. good points new to this version contain:

  • Several essentially vital proteins, reminiscent of globins, histones, insulin, and albumins, are incorporated to raised exhibit the right way to follow bioinformatics instruments to simple organic questions.
  • A thoroughly up to date companion internet site, in an effort to be up-to-date as new details turns into on hand - stopover at www.wiley.com/go/pevsnerbioinformatics
  • Descriptions of genome sequencing tasks spanning the tree of existence.
  • A better specialize in how bioinformatics instruments are used to appreciate human disorder.

The e-book is complemented by way of lavish illustrations and greater than 500 figures and tables—fifty of that are completely new to this variation. each one bankruptcy contains a challenge Set, Pitfalls, packing containers explaining key concepts and mathematics/statistics ideas, precis, urged studying, and a listing of freely on hand software program. Readers may possibly stopover at a comparable online page for supplemental details at www.wiley.com/go/pevsnerbioinformatics.

Bioinformatics and sensible Genomics, moment Edition serves as a great single-source textbook for complicated undergraduate and starting graduate-level classes within the organic sciences and machine sciences. it's also an integral source for biologists in a extensive number of disciplines who use the instruments of bioinformatics and genomics to check specific study difficulties; bioinformaticists and machine scientists who enhance machine algorithms and databases; and scientific researchers and clinicians who are looking to comprehend the genomic foundation of viral, bacterial, parasitic, or different ailments.

Praise for the 1st edition:

"...ideal either for biologists who are looking to grasp the applying of bioinformatics to real-world difficulties and for desktop scientists who have to comprehend the organic questions that encourage algorithms." Quarterly evaluation of Biology

"… a good textbook for graduate scholars and higher point undergraduate students." Annals of Biomedical Engineering

"…highly urged for educational and scientific libraries, and for researchers as an advent and reference…" E-StreamsContent:
Chapter 1 creation (pages 3–11):
Chapter 2 entry to series info and Literature details (pages 12–45):
Chapter three Pairwise series Alignment (pages 46–98):
Chapter four simple neighborhood Alignment seek software (BLAST) (pages 100–138):
Chapter five complicated Database looking out (pages 140–177):
Chapter 6 a number of series Alignment (pages 178–212):
Chapter 7 Molecular Phylogeny and Evolution (pages 214–275):
Chapter eight Bioinformatic methods to Ribonucleic Acid (RNA) (pages 279–328):
Chapter nine Gene Expression: Microarray info research (pages 330–376):
Chapter 10 Protein research and Proteomics (pages 378–418):
Chapter eleven Protein constitution (pages 420–459):
Chapter 12 sensible Genomics (pages 460–514):
Chapter thirteen accomplished Genomes (pages 517–565):
Chapter 14 accomplished Genomes: Viruses (pages 566–595):
Chapter 15 accomplished Genomes: micro organism and Archaea (pages 596–636):
Chapter sixteen The Eukaryotic Chromosome (pages 638–695):
Chapter 17 Eukaryotic Genomes: Fungi (pages 696–726):
Chapter 18 Eukaryotic Genomes: From Parasites to Primates (pages 728–788):
Chapter 19 Human Genome (pages 790–836):
Chapter 20 Human sickness (pages 838–889):

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Additional info for Bioinformatics and Functional Genomics, Second Edition

Sample text

1. We will define the bacteria, archaea, and eukaryotes in detail in Chapters 13 to 18. Briefly, eukaryotes have a nucleus and are often multicellular, whereas bacteria do not have a nucleus. Archaea are single-celled organisms, distinct from eukaryotes and bacteria, which constitute a third major branch of life. Viruses, which contain nucleic acids (DNA or RNA) but can only replicate in a host cell, exist at the borderline of the definition of living organisms. We have seen so far that GenBank is very large and growing rapidly.

1 million human ESTs, there is currently an average of over 300 ESTs corresponding to each human gene. In GenBank, the convention is to use the four DNA nucleotides when referring to DNA derived from RNA. 20 ACCESS TO SEQUENCE DATA AND LITERATURE INFORMATION TABLE 2-3 TopTen OrganismsforWhich ESTs Have Been Sequenced Organisms Homo sapiens Mus musculus þ domesticus Zea mays Arabidopsis thaliana Bos taurus Sus scrofa Danio rerio Glycine max Xenopus (Silurana) tropicalis Oryza sativa Common Name Number of ESTs Human Mouse Maize Thale cress Cattle Pig Zebrafish Soybean Western clawed frog Rice 8,138,094 4,850,602 2,002,585 1,526,133 1,517,139 1,476,546 1,379,829 1,351,356 1,271,375 1,220,908 Many thousand of cDNA libraries have been generated from a variety of organism, and the total number of public entries is currently over 58 million.

1. We will define the bacteria, archaea, and eukaryotes in detail in Chapters 13 to 18. Briefly, eukaryotes have a nucleus and are often multicellular, whereas bacteria do not have a nucleus. Archaea are single-celled organisms, distinct from eukaryotes and bacteria, which constitute a third major branch of life. Viruses, which contain nucleic acids (DNA or RNA) but can only replicate in a host cell, exist at the borderline of the definition of living organisms. We have seen so far that GenBank is very large and growing rapidly.

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Bioinformatics and Functional Genomics, Second Edition by Jonathan Pevsner


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