Read e-book online Bioinformatics and Molecular Evolution PDF

By Paul G. Higgs

ISBN-10: 1405106832

ISBN-13: 9781405106832

ISBN-10: 1444311182

ISBN-13: 9781444311181

Within the present period of entire genome sequencing, Bioinformatics and Molecular Evolution offers an updated and accomplished creation to bioinformatics within the context of evolutionary biology.

This obtainable textual content:

  • provides an intensive exam of series research, organic databases, development acceptance, and purposes to genomics, microarrays, and proteomics
  • emphasizes the theoretical and statistical tools utilized in bioinformatics courses in a manner that's available to organic technology students
  • places bioinformatics within the context of evolutionary biology, together with inhabitants genetics, molecular evolution, molecular phylogenetics, and their applications
  • features end-of-chapter difficulties and self-tests to assist scholars synthesize the fabrics and observe their understanding
  • is observed by way of a devoted web site - www.blackwellpublishing.com/higgs - containing downloadable sequences, hyperlinks to internet assets, solutions to self-test questions, and all art in downloadable structure (artwork additionally on hand to teachers on CD-ROM).

This vital textbook will equip readers with an intensive knowing of the quantitative tools utilized in the research of molecular evolution, and should be crucial interpreting for complex undergraduates, graduates, and researchers in molecular biology, genetics, genomics, computational biology, and bioinformatics classes.

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Extra info for Bioinformatics and Molecular Evolution

Sample text

We still have a lot more to learn about these signals. 2 RNA processing An RNA strand that is transcribed from a proteincoding region of DNA is called a messenger RNA (mRNA). The mRNA is used as a template for protein synthesis in the translation process discussed below. In prokaryotes, mRNAs consist of a central coding sequence that contains the information for making the protein and short untranslated regions (UTRs) at the 5′ and 3′ ends. The UTRs are parts of the sequence that were transcribed but will not be translated.

They estimated the free energy cost for removal of an amino acid from the bilayer to water. These two scales are similar but not identical; therefore both scales are shown in the table. Another property that is thought to be relevant for protein folding is the surface area of the amino acid that is exposed (accessible) to water in an unfolded peptide chain and that becomes buried when the chain folds. 2 shows the accessible surface areas of the residues when they occur in a Gly–X–Gly tripeptide (Miller et al.

The polymerase needs to know where to stop and start. This information is contained in the DNA sequence. A promoter is a short sequence of DNA bases that is recognized as a start signal by RNA polymerase. For example, in E. coli, most promoters have a sequence TATAAT about 10 nucleotides before the start point of Nucleic acids, proteins, and amino acids l 17 transcription and a sequence TTGACA about 35 nucleotides before the start. However, these sequences are not fixed, and there is considerable variation between genes.

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Bioinformatics and Molecular Evolution by Paul G. Higgs


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