Bioinformatics challenges at the interface of biology and by Teresa K. Attwood, Stephen R. Pettifer, David Thorne PDF

By Teresa K. Attwood, Stephen R. Pettifer, David Thorne

ISBN-10: 047003548X

ISBN-13: 9780470035481

ISBN-10: 0470035501

ISBN-13: 9780470035504

This cutting edge publication offers a totally clean exploration of bioinformatics, investigating its complicated interrelationship with biology and machine technological know-how. It ways bioinformatics from a different point of view, highlighting interdisciplinary gaps that frequently capture the unwary.

The booklet considers how the necessity for organic databases drove the evolution of bioinformatics; it studies bioinformatics fundamentals (including database codecs, data-types and present research methods), and examines key themes in laptop technological know-how (including data-structures, identifiers and algorithms), reflecting on their use and abuse in bioinformatics.

Bringing those disciplines jointly, this e-book is a necessary learn in the event you desire to greater comprehend the demanding situations for bioinformatics on the interface of biology and machine technology, and the way to bridge the gaps. it is going to be a useful source for complicated undergraduate and postgraduate scholars, and for teachers, researchers and execs with an curiosity during this interesting, fast-moving self-discipline and the knotty difficulties that encompass it.

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Acta Crystallographica, 6, 673–677; b) The structure of sodium thy­ monucleate fibres. II. The cylindrically symmetrical Patterson function. Acta Crystallographica, 6, 678–685; c) Molecular configuration in sodium thymonucleate. Nature, 171, 740–741. , Moore, S. H. (1960) the sequence of the amino acid residues in per­ formic acid‐oxidized ribonuclease. Journal of Biological Chemistry, 235, 633–647. Hogeweg, P. (1978) Simulating the growth of cellular forms. Simulation, 31, 90–96. Hogeweg, P. (2011) The roots of bioinformatics in theoretical biology.

1. Thus, for example, if it isn’t possible to resolve the abundance of A or T at a given position, the code W can be used; or, if no base can be assigned confidently at a particular position, we can indicate the ambiguity with the Chapter 2 The biological context 23 letter N. , at positions where purines may interchange, the code R can be used; or, where pyrimidines may interchange, we can use Y. The codes also find use when we wish to encapsulate patterns of conservation in particular regions of an alignment in the form of consensus expressions – we’ll discuss these in more detail in Chapter 4.

Genomics, 6, 389–391. , Sanger, F. and Kitai, R. (1955), The structure of pig and sheep insulins. Biochemical Journal, 60(4), 556–565. Cantor, C. (2000) Biotechnology in the 21st century. Trends in Biotechnology, 18, 6–7. A. R. (eds) (1965) Atlas of Protein Sequence and Structure. National Biomedical Research Foundation, Silver Spring, MD, USA. O. to Berkley, C. (1967) Margaret O. Dayhoff Papers, Archives of the National ­Biomedical Research Foundation, Washington, DC. Editorial. (2001) A cold dose of medicine.

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Bioinformatics challenges at the interface of biology and computer science: mind the gap by Teresa K. Attwood, Stephen R. Pettifer, David Thorne

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