Bioinformatics. From Genomes to Drugs by Thomas Lengauer, Raimund Mannhold, Hugo Kubinyi, Hendrik PDF

By Thomas Lengauer, Raimund Mannhold, Hugo Kubinyi, Hendrik Timmerman

ISBN-10: 3527299882

ISBN-13: 9783527299881

Presents a wide, application-oriented review of this expertise. The state of the art in bioinformatics is evaluated both from an international view through introducing actual software eventualities.

Show description

Read or Download Bioinformatics. From Genomes to Drugs PDF

Best bioinformatics books

Download e-book for iPad: Introduction to Genomics by Arthur M. Lesk

Our genome is the blueprint to our life: it encodes all of the details we have to increase from a unmarried mobile right into a highly complex sensible organism. yet how can we establish the genes that make up our genome? How will we make sure their functionality? and the way do various genes shape the regulatory networks that direct the tactics of existence?

Download e-book for iPad: Methods in Modern Biophysics by Bengt Nölting

Incorporating fresh dramatic advances, this textbook offers a clean and well timed advent to trendy biophysical equipment. An array of latest, swifter and higher-power biophysical tools now permits scientists to envision the mysteries of lifestyles at a molecular point. This cutting edge textual content surveys and explains the 10 key biophysical tools, together with these on the topic of biophysical nanotechnology, scanning probe microscopy, X-ray crystallography, ion mobility spectrometry, mass spectrometry, proteomics, and protein folding and constitution.

Bioinformatics and Data Analysis in Microbiology by Ozlem Tastan Bishop PDF

The swift development of sequencing recommendations, coupled with the recent methodologies of bioinformatics to address large-scale info research, are delivering interesting possibilities to appreciate microbial groups from various environments, past past mind's eye. This publication presents necessary, updated, and certain details on numerous facets of bioinformatics facts research with functions to microbiology.

Additional resources for Bioinformatics. From Genomes to Drugs

Example text

Modern secondary structure prediction methods are more involved though (see below). The functional features of proteins that are grasped by such parameters are manifold. Hydrophobic amino acids tend to occur in the interior of globular proteins, while at the surface of a protein one will preferentially ®nd hydrophilic residues. One application of the latter is the prediction of antigenic epitopes because these are assumed to coincide with patches of hydrophilic residues. In transmembrane proteins, the regions of the chain that span the membrane tend to be strongly hydrophobic and the recognition of several such regions is an integral part of methods aiming at the recognition of transmembrane proteins based on their sequence alone [9, 10].

2185±95. Huynen, M. , Y. Diaz-Lazcoz, and P. Bork, Di€erential genome display, Trends Genet, 1997. 13(10): p. 389±90. 1 Introduction Although a theoretical method to predict the three-dimensional structure of a protein from its sequence alone is not in sight yet, researchers have uncovered a multitude of connections between the primary sequence on one hand and various functional features of proteins on the other hand. Among the success stories are the recognition of transmembrane proteins or the classi®cation of proteins into classes of similar function based on sequence similarity.

Here, a set of compounds is preselected from a large library with virtual screening. These compounds are then tested in the laboratory. Chapter 6 of volume 2 by Matthias Rarey, Martin Stahl, and Gerhard Klebe gives more detail on virtual drug screening. 7) Recently, new experimental methods have been developed that uncover variations of genomic text for organisms of the same species. The sequencing data discriminate between di€erent external or internal states of the organism or provide insight into intra-species genetic variability.

Download PDF sample

Bioinformatics. From Genomes to Drugs by Thomas Lengauer, Raimund Mannhold, Hugo Kubinyi, Hendrik Timmerman

by Charles

Rated 4.33 of 5 – based on 42 votes