Bioinformatics. From Genomes to Drugs by Thomas Lengauer, Raimund Mannhold, Hugo Kubinyi, Hendrik PDF

By Thomas Lengauer, Raimund Mannhold, Hugo Kubinyi, Hendrik Timmerman

ISBN-10: 3527299882

ISBN-13: 9783527299881

Presents a wide, application-oriented review of this expertise. The state of the art in bioinformatics is evaluated both from an international view through introducing actual software eventualities.

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Modern secondary structure prediction methods are more involved though (see below). The functional features of proteins that are grasped by such parameters are manifold. Hydrophobic amino acids tend to occur in the interior of globular proteins, while at the surface of a protein one will preferentially ®nd hydrophilic residues. One application of the latter is the prediction of antigenic epitopes because these are assumed to coincide with patches of hydrophilic residues. In transmembrane proteins, the regions of the chain that span the membrane tend to be strongly hydrophobic and the recognition of several such regions is an integral part of methods aiming at the recognition of transmembrane proteins based on their sequence alone [9, 10].

2185±95. Huynen, M. , Y. Diaz-Lazcoz, and P. Bork, Di€erential genome display, Trends Genet, 1997. 13(10): p. 389±90. 1 Introduction Although a theoretical method to predict the three-dimensional structure of a protein from its sequence alone is not in sight yet, researchers have uncovered a multitude of connections between the primary sequence on one hand and various functional features of proteins on the other hand. Among the success stories are the recognition of transmembrane proteins or the classi®cation of proteins into classes of similar function based on sequence similarity.

Here, a set of compounds is preselected from a large library with virtual screening. These compounds are then tested in the laboratory. Chapter 6 of volume 2 by Matthias Rarey, Martin Stahl, and Gerhard Klebe gives more detail on virtual drug screening. 7) Recently, new experimental methods have been developed that uncover variations of genomic text for organisms of the same species. The sequencing data discriminate between di€erent external or internal states of the organism or provide insight into intra-species genetic variability.

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Bioinformatics. From Genomes to Drugs by Thomas Lengauer, Raimund Mannhold, Hugo Kubinyi, Hendrik Timmerman


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