By Devarajan Thangadurai, Jeyabalan Sangeetha
Reflecting the interdisciplinary nature of biotechnology, this publication covers the function of special supply of polymeric nanodrugs to melanoma cells, microbial detoxifying enzymes in bioremediation and bacterial plasmids in antimicrobial resistance. It addresses smooth traits equivalent to pharmacogenomics, review of gene expression, recombinant proteins from methylotrophic yeast, id of novel fermentation inhibitors of bioethanol construction, and polyhydroxyalkanoate established biomaterials. The ebook highlights the sensible software of biotechnology and bioinformatics for bioenergy, construction of excessive price biochemicals, modeling molecular interactions, drug discovery, and customized drugs.
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Additional resources for Biotechnology and Bioinformatics: Advances and Applications for Bioenergy, Bioremediation and Biopharmaceutical Research
Vital functions for lethal caspases. Oncogene 2005, 24, 5137–5148. ; Cho, E. ; Cho, K. Incorporation and release behavior of hydrophobic drug in functionalized poly(d, l-lactide)-blockpoly(ethylene oxide) micelles. J Control Rel 2004, 94, 323–335. Leroux, J. ; Gurnay, R. New approach for the preparation of nanoparticles by an emulsification-diffusion method. Eur J Pharm Biopharm 1995, 41, 14–18. ; Yuan, J. Caspases in apoptosis and beyond. Oncogene 2008, 27, 6194–6206. ; He, Z. Dual targeting folate-conjugated hyaluronic acid polymeric micelles for paclitaxl delivery.
Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo. Proc Natl Acad Sci USA 2011, 108(5), 1850–1855. ; Lipparda, S. J. Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate. Proc Natl Acad Sci USA 2009, 106(52), 22199−22204. ; Atyabi, F. Polylactide-coglycolide nanoparticles for controlled delivery of anticancer agents. Int J Nanomed 2011, 87, 78–95. ; Brauns, T. ; Gros, M. pH values on chronic wounds: evaluation during modern wound therapy.
Our study of HA-Pt NPs formed through anionic polymer-metal complexation between cisplatin and HA, has suggested no significant difference between cisplatin and HA-Pt cytotoxicity in vitro. However, HA-Pt maintains its cytotoxicity in conjugate form, although HA alone did not show any cytotoxic effects up to concentration as high as 10 mg/mL. The noncytotoxic nature of HA could remarkably reduce the systemic cytotoxicity and also enhance the accumulation of cisplatin towards the site of tumor via HA-CD44 receptor-ligand uptake mechanism.
Biotechnology and Bioinformatics: Advances and Applications for Bioenergy, Bioremediation and Biopharmaceutical Research by Devarajan Thangadurai, Jeyabalan Sangeetha