By Donald J. Abraham
This can be quantity 1: Drug Discovery, of Burger's Medicinal Chemistry and Drug Discovery, sixth version. This new quantity includes serious new chapters on digital Screening, Bioinformatics and Chemical info Computing structures in Drug Discovery.To buy the total 6 quantity set, please seek advice from ISBN 0-471-37032-0.For an entire record of articles and participants in addition to loose pattern chapters from this new sixth variation please stopover at: www.mrw.interscience.wiley.com/bmcdd
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Extra info for Burger's Medicinal Chemistry and Drug Discovery, Drug Discovery (Volume 1)
9. J. Ferguson, Proc. R. Soc. London Ser. B , 127, 387 (1939). 10. A. Albert, S. Rubbo, R. Goldacre, M. Darcy, and J. Stove, Br. J. Exp. , 26, 160 (1945). 11. A. , Chapman and Hall, London, 1985, p. 33. 12. P. H. Bell and R. 0. J. Am. Chem. ,64,2905 (1942). 13. L. P. Hammett, Chem. , 17,125 (1935). 14. L. P. , McGraw-Hill, New York, 1970. 15. R. W. Taft, J. Am. Chem. , 74,3120 (1952). 16. C. Hansch, P. P. Maloney, T. Fujita, and R. M. Muir, Nature, 194, 178 (1962). 17. R. Nelson Smith, C. Hansch, and M.
A comprehensive, integrated database C-QSAR allows us to do so; it contains over 16,000 examples drawn from all facets of chemistry and biology. An example on the toxicity of X-phenols will illustrate the usefulness of this database (164, 228, 235-238). Recently, increasing numbers of QSAR for phenols have been based on Brown's a+term, an electronic term that was first designed to rationalize electronic effects of substituents on electrophilicaromatic substitution. 109109 (239). 5. Cytotoxicity studies of X-phenols versus L1210 cells in culture led to an unusual result, which was b a n g but reminiscent of Hammett plots related to changes in mechanism (228).
L. P. , McGraw-Hill, New York, 1970. 15. R. W. Taft, J. Am. Chem. , 74,3120 (1952). 16. C. Hansch, P. P. Maloney, T. Fujita, and R. M. Muir, Nature, 194, 178 (1962). 17. R. Nelson Smith, C. Hansch, and M. M. Ames, J. Pharm. , 64,599 (1975). 18. T. Fujita, J. Iwasa, and C. Hansch, J. Am. Chem. , 86, 5175 (1964). 19. C. Hansch and A. Leo in S. R. , Exploring QSAR. Fundamentals and Applications in Chemistry and Biology, American Chemical Society, Washington, DC, 1995. 20. C. Hansch, Acc. Chem. , 2,232 (1969).
Burger's Medicinal Chemistry and Drug Discovery, Drug Discovery (Volume 1) by Donald J. Abraham