By Anatole A. Klyosov, Zbigniew J. Witczak, and David Platt (Eds.)
content material: evaluate. Carbohydrates and drug layout: what's new during this booklet / Anatole A. Klyosov --
Carbohydrate therapeutics: new advancements and techniques / Zbigniew J. Witczak --
melanoma. improvement of a polysaccharide as a automobile to enhance the efficacy of chemotherapeutics / David Platt, Anatole A. Klyosov, and Eliezer Zomer --
DAVANAT and colon melanoma: preclinical and medical (phase I) experiences / Anatole A. Klyosov, Eliezer Zomer, and David Platt --
Synthesis and organic task of doxo-galactose and doxo-galactomannan, new conjugates of doxorubicin with D-galactose and 1,4, [beta]-D-galactomannan / Anatole A. Klyosov ... [et al.] --
Human immunodeficiency virus. Carbohydrate-based vaccines opposed to HIV/Aids / Lai-Xi Wang --
towards a carbohydrate-based HIV-1 vaccine / Daniel Calarese ... [et al.] --
Pathogen administration. Cationic polysaccharides within the remedy of pathogenic Candida infections / Avital Mazar Ben-Josef, David Platt, and Eliezer Zomer --
New techniques in synthesis and computational experiences. artificial easy methods to contain [alpha]-linked 2-amino-2-deoxy-D-glucopyranoside and 2-amino-2-deoxy-D-galactopyranoside residues into glycoconjugate constructions / Robert J. Kerns and Peng Wei --
Systematic synthesis of aminosugars and their stereoselective glycosylation / Jinhua Wang and Cheng-Wei Tom Chang --
functional purposes of computational experiences of the glycosylation response / Dennis M. Whitfield and Tomoo Nukada.
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Extra info for Carbohydrate Drug Design
However, for an increasing number o f new experimental drugs (including some carbohydrate therapeutics) the situation is more complex and requires consideration o f many pharmaceutical, pharmacological, and pathological factors (Table 1). Table 1. Factors in drug delivery • D r u g polarity • D r u g size • D r u g stability • First-pass metabolism • Therapeutic index • D e l i v e r y route • Pharmacokinetics/Pharmacodynamics • Toxicity D r u g size (small molecule vs. oligosaccharide/polysaccharide) is one o f the few critical factors for the successful development o f a delivery system.
This account is devoted to examining these new developments in carbohydrate-drug design, with a focus on novel synthetic pathways and application of modern synthetic carbohydrate compounds as therapeutic agents. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2006. ch002 Introduction In the early 1980s the first studies o f carbohydrate-binding proteins prompted a new era o f research and development into the roles o f carbohydrates and carbohydrate-binding proteins i n biological systems.
A m i p r i l o s e specifically acts as an immunomodulator and therefore has a therapeutic effect on autoimmune disorders such as arthrithis, psoriasis, and, most importantly, systemic lupus. Therafectin has l o w toxicity and no serious side effects but is required i n large doses for effective therapy. (23). This particular factor creates a problem, e specially f or o ral a dministration, b ecause treatment o f inflammatory or autoimmune disorders is often chronic. CH 3 Figure I. Amiprilose (Therafectin) Because the bioavailabilities o f A m i p r i l o s e and Therafectin were not improved despite many efforts, their development was discontinued.
Carbohydrate Drug Design by Anatole A. Klyosov, Zbigniew J. Witczak, and David Platt (Eds.)