By Smith K.A.
Interleukin 2 (IL-2), initially termed T telephone progress issue (TCGF), used to be the 1st cytokine to be remoted, purified, and characterised on the molecular point. Structurally. IL-2 is prototypic of the interleukins. hematopoietic cytokines, and a few extra vintage hormones, reminiscent of development hormone and prolactin, in that it's a small globular glycoprotein, composed of 4 amphipathic antiparallel a helices. Functionally. IL-2 is a little odd of the interleukins. in that its construction is specific to simply antigen or mitogen-activated T lymphocytes (T cells), and its motion is particular to antigen-activated T cells and typical killer (NK) cells. IL-2 promotes the proliferation, differentiation, and survival of those objective cells, such that it's compulsory for a physiologic antigen-specific got mobile immune reaction, and it additionally augments the innate host defenses via its results on NK cells. IL-2 was once found to mediate those organic actions by means of binding to IL-2-specific receptors, that are expressed transiently on antigen-activated T cells and always by means of NK cells.