New PDF release: Coeliac Disease: 40 years gluten-free

By A. S. Peña (auth.), M. L. Mearin, C. J. J. Mulder (eds.)

ISBN-10: 9048140870

ISBN-13: 9789048140879

ISBN-10: 9401579431

ISBN-13: 9789401579438

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Gut 1975;16:393. 2 Shaw S, Pollack MS, Payne SM, Johnson AH. HLA-linked B cell antigens of a new segregant series: Population and family studies of the SB antigens. Hum Immunol 1985;1:145. 3 Nose Y, Nakatsuji T, Tsuji K, Reinsmoen NL. A new DP (SB) specificity (Cp63) defined in Japanese and caucasian cell populations by cloned PLT cells. Hum Immunol 1985;13:145. 4 Odum N, Hartzman RJ, Jakobsen BK, Morling N, Platz P, Jakobsen B, Svejgaard A The HLA DP polymorphism in Denmark investigated by local and international PLT reagents.

Lancet 1972;ii:162-4 Falchuck ZM, Rogentine GN, Strober W. Predominance of histocompatibility antigen HLA8 in patients with gluten-sensitive enteropathy. J Clin Invest 1972;51:1602-5. Betuel H, Gebuhrer L, Descos L, Percebois H, Minaire Y, Bertrand J. Adult celiac disease associated with HLA-DRw3 and -DRw7. Tissue Antigens 1980;15:231-42. Brautbar C, Freier S, Ashkenazi A, Dekelbaum R, Tur-Kasper I, Amar A, Cohen I, Sharon R, Abecassis R, Levine C, Cohen T, Albert E. Histocompatibility determinants in Israeli Jewish patients with coeliac disease: population and family study.

HUMAN IMMUNOGENETICS OF COELIAC DISEASE CD is characterized by small intestinal mucosal athrophy elicited by ingestion of wheat gluten in genetically susceptible individuals (1). 2% of the individuals which have the disease associated MHC genes develop CD despite the dietary intake of wheat (2). Interestingly, disease is not always concordant among monozygotic twins (3,4). Based on those observations it has been postulated that additional environmental factors may play a role in the pathogenesis of CD.

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Coeliac Disease: 40 years gluten-free by A. S. Peña (auth.), M. L. Mearin, C. J. J. Mulder (eds.)


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