By Herman Bachelard (auth.), Herman Bachelard (eds.)
The Advances in Neurochemistry sequence was once initiated for a readership of neuroscientists with a heritage in biochemistry. real to this idea, the current quantity brings jointly quite a few functions of magnetic resonance expertise to enhance our wisdom of ways the apprehensive procedure features. even if on the mobile, tissue slice, or intact organism point. magnetic resonance ideas are by way of their nature noninvasive, and hence offer a window in which biochemical reactions should be considered with no grinding, binding, or different clever perturbing ongoing physiological approaches. As technological increase ments in method, akin to better and extra uniform magnetic fields, novel paradigms for info research, and so on. , are made, we discover elevated sensitivity and enhanced temporal and spatial solution for practical imaging ideas at the one hand, and higher separation of indications that establish chemical homes in spectral shift stories, at the different. it truly is upon wisdom reminiscent of is defined within the twelve chapters that stick with, that additional advances in clinical discovery and the biomedical functions of the next day might be established. we're thankful to Dr. Bachelard, the amount Editor, and to the authors of the person chapters for his or her efforts. We additionally word that with this quantity Dr. Morris Aprison, a co-founder of the Advances in Neurochemistry sequence has stepped down and recognize with thank you his significant function in its inception. moreover, we thank our previous and current Advisory Editors. Bernard W. Agranoff Kunihiko Suzuki sequence Editors ix CONTENTS checklist OF SYMBOLS AND word list . . . . . . . . . . . . . . . . . . . . . . . . . . . XXI creation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Extra info for Magnetic Resonance Spectroscopy and Imaging in Neurochemistry
I (A. ), pp. 447-472. Plenum Press. New York. Brand. A .. Engelmann. J .. , 1992, A 13C NMR study on fluxes into the TCA cycle of neuronal and glial tumor cell lines and primary cells, Biochimie 74:941-948. , 1993, Multinuclear NMR studies on the energy metabolism of glial and neuronal cells, Del'. Neurosci. 15:289-298. , and Herschkowitz. Noo 1990. Brain development: I H magnetic resonance spectroscopy ofrat brain extracts compared with chromatographic methods, Neurochem. Res. 15:009- 10 16. , Kunnecke.
3) and glutamine were only visible in the spectra of the extracts from astrocytes. The glutamate peak in these spectra is larger in the case of the granule neurons than in that of the astrocytes, in agreement with the role of granule cells as glutamatergic neurons. Glutamine synthetase is exclusively located in astrocytes (Norenberg and Martinez-Hernandez, 1979), and hence glutamine is observed in larger amounts in astrocytes than in neurons. Some major metabolites visible in the t H spectra of incubation media from astrocytes were glutamine, citrate, and succinate (Fig.
Magnetic Resonance Spectroscopy and Imaging in Neurochemistry, Volume S of Advances ill Neurochemistry ecJilecJ by Bachclard. Plenum Pre". New York. 1997. , Ca 2+, Cd 2+, Fe 2+, Pb 2+, and Zn 2+) can now be routinely followed using 19F-MRS indicators. These have the advantage over fluorescence techniques that many cations can be measured simultaneously due to their specific chemical shifts. Specific MRS probes have also been developed to enable measurement of intracellular pH and Na+. Whereas the noninvasive techniques can readily be used in vivo in the human brain, only a few of these invasive approaches are currently applicable to animal brains in vivo.
Magnetic Resonance Spectroscopy and Imaging in Neurochemistry by Herman Bachelard (auth.), Herman Bachelard (eds.)